CJC-1295 Without DAC: Complete Research Guide — Modified GRF(1-29), Pulsatile GH Data & White-Label Pricing (2026)
Quick Summary
- CJC-1295 without DAC (CAS: 863288-34-0) is a 29-amino acid modified analog of growth hormone-releasing hormone, also known as Modified GRF(1-29) or Mod GRF(1-29), with four amino acid substitutions that extend its effective half-life from approximately 5 minutes to 30 minutes.
- Published pharmacokinetic data demonstrated dose-dependent increases in GH secretion with mean peak GH levels of 8–13 ng/mL in healthy subjects, preserving physiological pulsatile release patterns unlike continuous GH administration (Teichman et al., 2006 — PMID: 16352683).
- The “without DAC” designation distinguishes this compound from CJC-1295 with DAC (compound Affinity Complex), which uses a maleimide linker to bind serum albumin and extend half-life to 6–8 days — a critical distinction for researchers designing pulsatile vs. sustained GH-axis protocols.
- Frequently paired with ghrelin-receptor agonists such as Ipamorelin (Research Use Only), the combination activates complementary GH-release pathways and represents the most-requested research pairing in the YPB catalog.
- Research-grade CJC-1295 without DAC is available through the YPB research catalog in a 10mg configuration with batch-specific COAs.
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