2X Blend: Complete Research Guide — CJC-1295 + Ipamorelin Dual-Receptor GH Data (2026)
Quick Summary
- The 2X Blend is a dual-compound research formulation combining CJC-1295 without DAC (5mg) and Ipamorelin (5mg) — a GHRH receptor agonist paired with a selective ghrelin receptor (GHS-R1a) agonist.
- The combination targets two distinct receptor systems on the same pituitary somatotroph population, engaging both cAMP-dependent GHRH signaling and calcium-dependent ghrelin signaling simultaneously.
- Published research by Gobburu et al. (1999, PMID: 10372741) demonstrated that simultaneous stimulation of both pathways produces a GH response greater than the sum of either compound used independently.
- Ipamorelin’s selectivity profile — minimal cortisol, prolactin, and ACTH elevation compared to earlier-generation GHRPs — positions this blend as the preferred dual-receptor model in modern GH-axis research.
- No published human randomized controlled trial has evaluated this exact combined formulation. The mechanistic rationale rests on receptor-level data from each component peptide studied independently.
- YPB ships the 2X Blend (YPB.238) under white-label for 250+ research brands at $40.15 Premier wholesale / $90 MSRP / $49.85 margin (55%). Updated April 2026.
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