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GHK-Cu: Complete Research Guide — Copper Peptide Gene Expression, Wound Healing & White-Label Data (2026)
Quick Summary
- GHK-Cu (glycyl-L-histidyl-L-lysine copper(II), CAS: 49557-75-7) is a naturally occurring tripeptide-copper complex with a molecular weight of 403.93 Da, first isolated from human plasma by Pickart and Thaler in 1973 at a concentration of approximately 200 ng/mL in young adults.
- Genome-wide expression profiling revealed that GHK-Cu modulates the activity of over 4,000 human genes at nanomolar concentrations — resetting gene expression patterns associated with aging, fibrosis, and tissue damage toward profiles characteristic of younger, healthier tissue (Pickart et al., Int J Mol Sci, 2018 — PMID: 30011848).
- Plasma GHK-Cu concentration declines approximately 60% with age — from ~200 ng/mL at age 20 to ~80 ng/mL by age 60 — correlating with reduced wound healing capacity, decreased collagen synthesis, and progressive tissue deterioration observed in aging research models.
- GHK-Cu search interest has grown over 1,000% year-over-year, making it the fastest-growing compound by search volume in the YPB healing and recovery category, driven by expanding applications across wound healing, dermal, and neuroprotection research.
- Research-grade GHK-Cu is available through the YPB research catalog in a 100mg configuration and as part of the GLOW Blend (Research Use Only) with batch-specific COAs.
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